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- Original papers
Original papers
M. Ueda, S. Takahashi, J. Ishida, A. Yamagami, T. Nakano, F. Pünner, M. Akakabe, Y. Sohtome, A. J. Nagano, M. Sodeoka, M. Seki
“A pyrazole partially induces brassinosteroid-related gene expression, leading to salt stress sensitivity”
J. Plant Growth Regul. in press.
F. Pünner, Y. Sohtome,* Y. Lyu, D. Hashizume, M. Akakabe, M. Yoshimura, Y. Yashiroda, M. Yoshida, M. Sodeoka*
“Catalytic Aerobic Carbooxygenation for the Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexasubstituted γ-Lactones”
Angew. Chem. Int. Ed. 63, e202405876 (2024)
T. Shimazu*, R. Yoshimoto, K. Kotoshiba, T. Suzuki, S. Matoba, M. Hirose, M. Akakabe, Y. Sohtome, M. Sodeoka, A. Ogura, N. Dohmae, Y. Shinkai*
“Histidine N1-position specific methyltransferase CARNMT1 targets C3H Zinc finger proteins and modulates RNA metabolism”
Genes. Dev. 37, 724–742 (2023).
Y. Sohtome,* S. Komagawa, A. Nakamura, D. Hashizume, S. Lectard, Y. Hamashima, M. Uchiyama, M. Sodeoka*
“Experimental and Computational Investigation of Facial Selectivity Switching in Nickel–Diamine–Acetate-Catalyzed Michael Reactions”
J. Org. Chem. 88, 7763–7773 (2023). (Special Issue: Modern Enantioselective Catalysis in Organic Chemistry)
M. Sugawara, M. Sawamura, M. Akakabe, B. Ramadoss, Y. Sohtome,* M. Sodeoka*
“Pd-catalyzed Aerobic Cross-Dehydrogenative Coupling of Catechols with 2-Oxindoles and Benzofuranones: Reactivity Difference between Monomer and Dimer”
Chem. Asian. J. 17, e2022000807 (2022).
Y. Sohtome,* M. Sodeoka*
“Theoretical Insights into the Substrate-Dependent Diastereodivergence in (3 + 2) Cycloaddition of α-Keto Ester Enolates with Nitrones”
Chem. Pharm. Bull. 70, 616–623 (2022). (Special Issue: Recent Advances in Molecular Space Chemistry)
K. Sasaki,* M. Suzuki, T. Sonoda, T. Schneder-Poetsch, A. Ito, M. Takagi, S. Fujishiro, Y. Sohtome, K. Dodo, K. Shin-ya, Y. Nakao, M. Sodeoka, M. Yoshida*
“Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and the HP1α chromodomain in living cells”
Cell. Chem. Biol. 29, 1153–1161 (2022).
E. Matsuura-Suzuki, T. Shimazu,* M. Takahashi, K. Kotoshiba, T. Suzuki, K. Kashiwagi, Y. Sohtome, M. Akakabe, M. Sodeoka, N. Dohmae, T. Ito,* Y. Shinkai,* S. Iwasaki*
“METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance”
eLife 11, e72780 (2022).
T. Ezawa,# Y. Sohtome, #,* D. Hashizume, M. Adachi, M. Akakabe, H. Koshino, M. Sodeoka* (#: equal contribution)
“Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates”
J. Am. Chem. Soc. 143, 9094–9104 (2021).
E. Davydova, T. Shimazu, M. Schuhmacher, M. E. Jakobsson, T. Liu, H. L.D.M. Willemen, A. Moen, A. Y.Y. Ho, J. Małecki, L. Schroer, R. Pinto, T. Suzuki, I. A. Grønsberg, Y. Sohtome, M. Akakabe, S. Weirich, M. Kikuchi, J. V. Olsen, N. Dohmae, T. Umehara, M. Sodeoka, V. Siino, M. McDonough, N. Eijkelkamp, C. J. Schofield, A. Jeltsch*, Y. Shinkai,* P. Ø. Falnes*
“The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes”
Nat. Commun. 12, 891 (2021).
- RIKEN press release
- International collaboration
M. Sugawara,# R. Ohnishi, T. Ezawa, M. Akakabe, M. Sawamura, D. Hojo, D. Hashizume, Y. Sohtome,#,* M. Sodeoka* (#: equal contribution)
“Regiodivergent Oxidative Cross-Coupling of Catechols with Persistent tert-Carbon Radicals”
ACS Catal. 10, 12770–12782 (2020).
R. Ohnishi, M. Sugawara, T. Ezawa, Y. Sohtome,* M. Sodeoka*
“Formal aerobic oxidative cross-coupling of benzofuranones with azo compounds using Pd-µ-hydroxo complex”
Chem. Pharm. Bull. 68, 895–898 (2020).
R. Ohnishi, M. Sugawara, M. Akakabe, T. Ezawa, H. Koshino, Y. Sohtome,* M. Sodeoka*
“Cross-Coupling Reaction of Dimer-Derived Persistent Tertiary-Carbon-Centered Radicals with Azo Compounds”
Asian J. Org. Chem. 8, 1017–1023 (2019). (Heterocyclic Chemistry Special Issue)
- Top downloaded paper 2018-2019
T. Tsusaka, M. Kikuchi, T. Shimazu, T. Suzuki, Y. Sohtome, M. Akakabe, M. Sodeoka, N. Dohmae, T. Umehara, Y. Shinkai*
“Tri-methylation of ATF7IP by G9a/GLP recruits a chromodomain protein MPP8”
Epigenet. Chromatin 11: 56 (2018).
Y. Sohtome, T. Shimazu, B. Joaquin, S. Fujishiro, M. Akakabe, N. Terayama, K. Dodo, A. Ito, M. Yoshida, Y. Shinkai, M. Sodeoka*
“Unveiling Epidithiodiketopiperazine as a Non-Histone Arginine Methyltransferase inhibitor by Chemical Protein Methylome Analyses”
Chem. Commun. 54, 9202–9205 (2018).
S. L. Bartlett, Y. Sohtome,* D. Hashizume, P. S. White, M. Sawamura, J. S. Johnson,* M. Sodeoka*
“Catalytic Enantioselective [3+2] Cycloaddition of α-Keto Ester Enolates and Nitrile Oxides”
J. Am. Chem. Soc. 139, 8661–8666 (2017).
Y. Sohtome,* G. Nakamura, A. Muranaka, D. Hashizume,* S. Lectard, T. Tsuchimoto, M. Uchiyama, M. Sodeoka*
“Naked d-Orbital in a Centrochiral Ni(II) Complex as a Catalyst for Asymmetric [3+2] Cycloaddition”
Nat. Commun. 8, 14875 (2017).
- Chem-Station
- RIKEN Research
- It Ain’t Magic
Y. Sohtome,* M. Sugawara, D. Hashizume, D. Hojo, M. Sawamura, A. Muranaka, M. Uchiyama, M. Sodeoka*
“Reversibility of 3-Phenyl-2-Oxindole Dimer Formation: Application to Construct Compounds with Two Distinct Vicinal All-carbon Quaternary Centers”
Heterocycles 95, 1030–1040 (2017). (Prof. Masakatsu Shibasaki’s Special Issue)
F. Pünner, Y. Sohtome, M. Sodeoka*
“Solvent Dependent Copper-catalyzed Synthesis of Pyrazoles under Aerobic Conditions”
Chem. Commun. 52, 14093–14096 (2016).
Back Cover: Chem. Commun. 52, 14174 (2016).
M. Kato, S, Hirao, M. Nakano, M. Yamanaka, Y. Sohtome,* K. Nagasawa*
“Entropy-Driven 1,2-Type Friedel-Crafts Reaction of Phenols with N-Boc Aldimines”
Chem. Eur. J. 51, 18606–18612 (2015).
Hot Paper, Frontispiece, ChemistryView
T. Shimazu, J. Barjau, Y. Sohtome, M. Sodeoka, Y. Shinkai*
“Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase”
PLOS ONE. 9, e105394 (2014).
N. Horitsugi, K. Kojima, K. Yasui, Y. Sohtome, K. Nagasawa*
“Asymmetric Michael Reaction of Nitroolefins with β-Dicarbonyl Compounds Catalyzed by 1,3-Diamin-Tethered Guanidine-Thiourea Bifunctional Organocatalyst”
Asian J. Org. Chem. 3, 445–448 (2014). (Special Issue for Organocatalysis)
S. Fujishiro, K. Dodo, E. Iwasa, Y. Teng, Y. Sohtome, Y. Hamashima, A. Ito, M. Yoshida, M. Sodeoka*
“Epidithiodiketopiperazine as a Pharmacophore for Protein Lysine Methyltransferase G9a Inhibitors: Reducing Cytotoxicity by Structural Simplification”
Bioorg. Med. Chem. Lett. 23, 733–736 (2013).
Y. Sohtome,* T. Yamaguchi, S. Tanaka, K. Nagasawa*
“Sequential enantiodivergent organocatalysis: reversibility in enantioswitching controlled by a conformationally flexible guanidine/bisthiourea organocatalyst”
Org. Biomol. Chem. 11, 2780–2786 (2013). (Prof. A. D. Hamilton’s Special Issue)
- Most Read Articles
Y. Sohtome,* N. Horitsugi, R. Takagi, K. Nagasawa*
“Enantioselective Phospha-Michael Reaction of Diphenyl Phosphite with Nitroolefins Utilizing Conformationally Flexible Guanidine/Bisthiourea Organocatalyst: Assembly-State Tunability in Asymmetric Organocatalysis”
Adv. Synth. Catal. 353, 2631–2636 (2011).
Y. Sohtome,* B. Shin, N. Horitsugi, K. Noguchi, K. Nagasawa*
“Linking the Conformational Flexibility and Kinetics: Catalytic 1,4-Type Friedel-Crafts Reaction of Phenols Utilizing 1,3-Diamine-Tethered-Guanidine/Bisthiourea Organocatalysts”
Chem. Asian. J. 6, 2463–2470 (2011).
Y. Sohtome,* T. Yamaguchi, B. Shin, K. Nagasawa*
“Organocatalytic Asymmetric Synthesis of N,N-Bis(dihydrofuranyl)hydroxyamines: A Cascade Reaction Involving Friedel-Crafts Alkylation, Internal Redox Reaction and Umpolung”
Chem. Lett. 40, 843–845 (2011).
- Top Accessed Article
- SYNFACTS 2011, 8, 1359
Y. Sohtome,* S. Tanaka, K. Takada, T. Yamaguchi, K. Nagasawa*
“Solvent-Dependent Enantiodivergent Mannich-Type Reaction: Utilizing Conformational Flexible Guanidine/Bisthiourea Organocatalyst”
Angew. Chem. Int. Ed. 49, 9254–9257 (2010).
- Top Accessed Article
- SYNFACTS 2011, 8, 100
Y. Sohtome,* S. Bongki, N. Horitsugi, R. Takagi, K. Noguchi, K. Nagasawa*
“Entropy-Controlled Catalytic Asymmetric 1,4-Type Friedel-Crafts Reaction of Phenols Using A Conformationally Flexible Guanidine/Bisthiourea Organocatalyst”
Angew. Chem. Int. Ed. 49, 7299–7303 (2010).
- Top Accessed Article
- SYNFACTS 2011, 7, 1303
Y. Sohtome, N. Takemura, R. Takagi, Y. Hashimoto, K. Nagasawa*
“Thiourea-Catalyzed Morita-Baylis-Hillman Reaction”
Tetrahedron 64, 9423–9429 (2008).
Y. Sohtome, Y. Kato, S. Handa, N. Aoyama, K. Nagawa, S. Matsunaga, M. Shibasaki*
“Stereodivergent Catalytic Doubly Diastereoselective Nitroaldol Reactions Using Heterobimetallic Complexes”
Org. Lett. 10, 2231–2234 (2008).
- SYNFACTS 2008, 5, 837
K. Takada, N. Takemura, K. Cho, Y. Sohtome,* K. Nagasawa*
“Asymmetric Organocatalytic Nitroaldol Reaction of α-Ketoesters: Stereoselective Construction of Chiral Tertiary Alcohols at Subzero Temperature”
Tetrahedron Lett. 49, 1623–1626 (2008).
M. Morita, T. Sone, K. Yamatsugu, Y. Sohtome, S. Matsunaga, M. Kanai,* Y. Watanabe, M. Shibasaki*
“A Method for the Synthesis of an Oseltamivir PET Tracer”
S. Handa, K. Nagawa, Y. Sohtome, S. Matsunaga,* M. Shibasaki*
“A Heterobimetallic Pd-La-Schiff Base Complex for anti-Selective Nitroaldol Reactions and Application to Short Synthesis of β-Adrenoceptor Agonists”
Angew. Chem. Int. Ed. 47, 3230–3233 (2008).
- SYNFACTS 2008, 5, 837
- SYNFACTS of the Month
H. Mihara, Y. Sohtome, S. Matsunaga,* M. Shibasaki*
“Chiral Catalyst-based Convergent Synthesis of HIV Protease Inhibitor GRL-06579A”
Chem. Asian. J. 3, 359–366 (2008). (Prof. Mukaiyama’s Special Issue).
H. Kakei, T. Sone, Y. Sohtome, S. Matsunaga,* M. Shibasaki*
“Catalytic Asymmetric Cyclopropanation of Enones with Dimethyloxosulfonium Methylide Promoted by a La-Li3-(Biphenyldiolate)3 + NaI Complex”
Y. Sohtome, N. Takemura, K. Takada, R. Takagi, T. Iguchi, K. Nagasawa*
“Organocatalytic Asymmetric Nitroaldol Reaction: Cooperative Effects of Guanidine and Thiourea Functional Groups”
Chem. Asian. J. 2, 1150–1160 (2007).
- Most Cited Articles Published in 2006/2007
- Most Accessed Articles in 07~10/2007
M. Tera, Y. Sohtome, H. Ishizuka, T. Doi, M. Takagi, K. Shin-ya,* K. Nagasawa*
“Design and Synthesis of Telomestatin Derivatives and Their Inhibitory Activity of Telomerase”
Heterocycles 69, 505–514 (2006). (Dr. Omura’s Special Issue).
Y. Sohtome, Y. Hashimoto, K. Nagasawa*
“Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing Guanidine-Thiourea Bifunctional Organocatalyst”
Eur. J. Org. Chem. 2894–2897 (2006).
- Most Accessed Articles in 2006
- Most Cited Articles Published in 2006/2007
Y. Sohtome, N. Takemura, T. Iguchi, Y. Hashimoto, K. Nagasawa*
“Diastereoselective Henry Reaction Catalyzed by Guanidine-Thiourea Bifunctional Organocatalyst”
Synlett 144–146 (2006). (Cluster Issue).
Y. Sohtome, Y. Hashimoto, K. Nagasawa*
“Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction”
Adv. Synth. Catal. 347, 1643–1648 (2005). (Catalytic C–C Bond Formation Issue)
- Most Cited Articles Published in 2005/2006
- Highly Cited Paper in ESI
Y. Sohtome, A. Tanatani, Y. Hashimoto, K. Nagasawa*
“Development of Bis-Thiourea-type Organocatalyst for Asymmetric Baylis-Hillman Reaction”
Tetrahedron Lett. 45, 5589–5592 (2004).
- Tetrahedron Letters Most Cited Paper 2003-2006 Award
- Tetrahedron Letters Most Cited Paper 2004-2007 Award
Y. Sohtome, A. Tanatani, Y. Hashimoto, K. Nagasawa*
“Development of Novel Chiral Urea Catalysts for the Hetero-Michael Reaction”
Chem. Pharm. Bull. 52, 477–480 (2004).
Y. Sohtome, T. Tokunaga, K. Ueda, S. Yamamura,* M. Ueda*
“Leaf-closing Substance in Leucaena Leucocephalam”
M. Ueda,* Y. Sohtome, K. Ueda, S. Yamamura*
“Potassium 2,3,4-Trihydroxy-2-methylbutanoate, a Leaf-closing Substance of Leucaena Leucocephalam”
Tetrahedron Lett. 42, 3109–3111 (2001).